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IMP3 promotes chemo-resistance in breast cancer cells by regulating BCRP (ABCG2) expression.

J Biol Chem. 2013 Mar 28;

Authors: Samanta S, Pursell B, Mercurio AM


IMP3, a member of a family of insulin-like growth factor II (IGF-II) mRNA binding proteins (IMPs), is expressed preferentially in triple-negative breast cancers, which are resistant to many chemotherapeutics. However, the mechanisms by which it impacts breast cancer have not been elucidated. We hypothesized a role for IMP3 in chemo-resistance based on these observations. Depletion of IMP3 expression in triple-negative breast cancer cells increased their sensitivity to doxorubicin and mitoxantrone significantly but not to taxol. Given that doxorubicin and mitoxantrone are effluxed by breast cancer resistance protein (BCRP), we assessed whether IMP3 regulates BCRP. The data obtained demonstrate that IMP3 binds directly to the 3-prime UTR of BCRP mRNA and regulates BCRP expression. These findings are significant because they provide insight into the mechanism by which IMP3 contributes to aggressive cancers and they highlight the potential for targeting this mRNA binding protein for the clinical management of cancer.

PMID: 23539627 [PubMed - as supplied by publisher]