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1. Diagn Pathol. 2012 Mar 27;7(1):32. [Epub ahead of print]

Hypoxia-inducible factor-2a is associated with ABCG2 expression, histology-grade
and Ki67 expression in breast invasive ductal carcinoma.

Xiang L, Liu ZH, Huan Q, Su P, Du GJ, Wang Y, Gao P, Zhou GY.

ABSTRACT: BACKGROUND: Breast cancer is the most common cancer and the leading
cause of cancer mortality in women worldwide. Hypoxia is an important factor
involved in the progression of solid tumors and has been associated with various
indicators of tumor metabolism, angiogenesis and metastasis. But little is known
about the contribution of Hypoxia-Inducible Factor-2a (HIF-2a) to the drug
resistance and the clinicopathological characteristics in breast cancer. METHODS:
Immunohistochemistry was employed on the tissue microarray paraffin sections of
surgically removed samples from 196 invasive breast cancer patients with
clinicopathological data. The correlations between the expression of HIF-2a and
ABCG2 as well as other patients' clinicopathological data were investigated.
RESULTS: The results showed that HIF-2a was expressed in different intensities
and distributions in the tumor cells of the breast invasive ductal carcinoma. A
positive staining for HIF-2a was defined as a brown staining observed mainly in
the nucleus. A statistically significant correlation was demonstrated between
HIF-2a expression and ABCG2 expression (p = 0.001), histology-grade (p = 0.029),
and Ki67 (p = 0. 043) respectively. CONCLUSION: HIF-2a was correlated with ABCG2
expression, histology-grade and Ki67 expression in breast invasive ductal
carcinoma. HIF-2a could regulate ABCG2 in breast cancer cells, and could be a
novel potential bio-marker to predict chemotherapy effectiveness. The
hypoxia/HIF-2a/ABCG2 pathway could be a new mechanism of breast cancer
multidrug-resistance. Virtual slides

PMID: 22452996 [PubMed - as supplied by publisher]