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4-Substituted-2-phenylquinazolines as inhibitors of BCRP.

Bioorg Med Chem Lett. 2012 Aug 15;

Authors: Juvale K, Wiese M


We investigated several 2-phenylquinazolines with different substitutions at position 4 for their BCRP inhibition. Compounds with phenyl ring attached via an amine-containing linker at position 4 were found to be potent inhibitors of BCRP. In general compounds with meta substitution of phenyl ring at position 4 were found to have higher inhibitory effect, compound 12 being the most potent and selective towards BCRP.

PMID: 23017888 [PubMed - as supplied by publisher]